{"id":118252,"date":"2023-07-17T10:42:35","date_gmt":"2023-07-17T10:42:35","guid":{"rendered":"https:\/\/websitedesigns.com.au\/elankanew\/?p=118252"},"modified":"2023-07-17T10:44:33","modified_gmt":"2023-07-17T10:44:33","slug":"mitochondrial-diseases-by-harold-gunatillake","status":"publish","type":"post","link":"https:\/\/websitedesigns.com.au\/elankanew\/mitochondrial-diseases-by-harold-gunatillake\/","title":{"rendered":"Mitochondrial diseases &#8211; By Harold Gunatillake"},"content":{"rendered":"<h2 style=\"text-align: center;\"><span style=\"color: #800000;\"><strong>Mitochondrial diseases &#8211; <span style=\"color: #808000;\">By Harold Gunatillake<\/span><\/strong><\/span><\/h2>\n<p><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-77916 aligncenter\" src=\"https:\/\/websitedesigns.com.au\/elankanew\/wp-content\/uploads\/2021\/11\/Harold-Gunethilake.jpg\" alt=\"Harold-Gunethilake\" width=\"160\" height=\"160\" \/><\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/-LE8CCy7IPY\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>Website:<a href=\"http:\/\/www.Doctorharold.com\" target=\"_blank\" rel=\"noopener\"> www.Doctorharold.com<\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Mitochondria-an organelle found in large numbers in most cells, in which the biochemical processes of respiration and energy production occur. It has a double membrane, the inner part being folded inwards to form layers (cristae).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">First, before we discuss mitochondrial dysfunctions or diseases, we need to understand what mitochondria are. It is a structure found in the cytoplasm of every cell in your body, covered by two thin membranes, the inner one corrugated, that generate most of the chemical energy needed to power the cell\u2019s biochemical reactions. It is an energy powerhouse. The word cytoplasm refers to the fluid that surrounds the cell nucleus. The chemical energy produced by these organelles is stored within the cells in a small molecule called adenosine triphosphate or ATP.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">When your mitochondria function properly, storing energy in ATP, and using that energy to perform your daily activities, you can be considered a healthy energetic person. If you are tired during the day without much energy in you, you could be having an early mitochondrial dysfunction. Your doctor will order a blood test called CRP to check whether there is some active disease process starting.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">The mitochondria are responsible for creating more than 90% of the energy needed by the body to<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">sustain support organ functions.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Now what are the roles of mitochondria?<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">1. Produces energy and stores ATP.<\/span><\/p>\n<p><span style=\"font-size: 16px; color: #000000;\">ATP is a complex organic chemical found in all forms of life and is often referred to as the molecular unit of currency because it powers metabolic processes.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">2. Responsible for cell death<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">3. Stores calcium<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">4. Produces heat.<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">5. Regulates innate immunity.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Mitochondria are responsible for converting glucose into energy. People with diabetes have a degree<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">of dysfunction in the mitochondria for glucose to produce energy fast. Normally such energy given by<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">glucose is stored in ATP in the mitochondria. In short, ATP is energy. This stored energy is used for<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">the functions of the body.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">In diabetes, there is no luck to have sufficient stored energy from glucose, due to mitochondrial dysfunction. Diabetics do not secrete sufficient insulin for glucose to be stored in the\u00a0 mitochondria to produce energy stored as ATP.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Fatty acids from dietary fat are taken to the fat cells or adipocytes and the mitochondria store them as ATP for energy.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Likewise, blood glucose with the help of insulin enters fat cells by converting it into triglycerides in the<\/span><br \/>\n<span style=\"font-size: 16px; color: #000000;\">liver. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">So, repeating,<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Excess glucose gets stored in the liver as glycogen or, with the help of insulin, converted into fatty acids circulated to other parts of the body, and stored as fat in adipose tissue. When there is an overabundance of fatty acids, fat also builds up in the liver.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">So both glucose and fatty acids as triglycerides get stored in the liver as fat. That is how fatty livers are\u00a0so common today among people globally.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\"><strong>What are the dangers of having a fatty liver?<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Early-stage NAFLD does not usually cause any harm, but it can lead to serious liver damage, including cirrhosis if it gets worse. Having high levels of fat in your liver is also associated with an increasedrisk of serious health problems, such as diabetes, high blood pressure, and kidney disease.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">So remember this serious man-made disease, so prevalent today in Sri Lanka, due to eating street and restaurant foods, and not home-cooked food.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">So, diabetes can be defined as a disease or dysfunction in the mitochondria leading to decreased ATP production, resulting in insulin resistance. This explains why they have less energy production in the cells and most symptoms are related to this.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">This situation leads to cell injury and cell death. Morbidity and mortality are high in diabetes due to mitochondrial dysfunction.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Mitochondrial diseases can affect any part of the body, including the cells of the nerves, muscles, Kidneys, heart, eye, brain, liver, and ears. Due to loss of energy in the organs in mitochondrial dysfunction, multiple organ cells die and lead to organ failure. About 1 in 5000 individuals have a genetic mitochondrial disease.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\"><strong>How do you reverse mitochondrial damage?<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">There is no cure for mitochondrial disease. Certain supplements\u2014thiamine (B1), riboflavin (B12), vitamin C, vitamin E, Lipoic acid, and coenzyme Q10\u2014may help treat certain aspects of the disease. Avoiding stress may also help reduce symptoms.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\"><strong>Exercise for mitochondrial health?<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Perform interval training to sustain fitness and optimize mitochondria. Training 2 to 4 days a week is ideal, with workouts such as brisk walking for 2-3 hours a day would minimize mitochondrial dysfunction.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Everyone knows that exercise is good for you. It is that one thing that has no downside. It makes you stronger, quicker, and smarter. It fixes your metabolism, protects your nervous system and other organs, and boosts your mood. What this all means is that dysfunctional mitochondria get back to their normal functions. Within you, every cell\u2019s mitochondria function well to store energy and provide it when required.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">This is so true in diabetes. Walking daily alone with no medication can reverse diabetes type 2 and reverse mitochondrial dysfunction. Walking seems to make resistant insulin work more sensitively.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">In life, if you wish to lead a wholesome healthy life the best drugs are plant-based foods and daily brisk walks.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Hope this video article will help you to adjust your lifestyle, accordingly. Stay safe and goodbye until we meet again.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">You can improve your mitochondrial baseline through exercise. Research shows that working out is the best way to increase the number of mitochondria in the cells and it improves their quality.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Disclaimer:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">The information contained in this article is for general information purposes only, and whilst the author will endeavour to keep the information up to date and correct, eLanka makes no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the eLanka website or the information, products, services, or related graphics contained in this article for any purpose. Any reliance you place on such information is therefore strictly at your own risk. In other words, eLanka In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website \/ article. Also please note that through this website \/ web page articles you are able to link to other websites which are not under the control of eLanka and therefore we have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mitochondrial diseases &#8211; By Harold Gunatillake Website: www.Doctorharold.com Mitochondria-an organelle found in large numbers in most cells, in which the biochemical processes of respiration and energy production occur. It has a double membrane, the inner part being folded inwards to form layers (cristae). First, before we discuss mitochondrial dysfunctions or diseases, we need to understand [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":118253,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"footnotes":""},"categories":[20,1103],"tags":[872,54059,40736,45714,54058,54060],"class_list":{"0":"post-118252","1":"post","2":"type-post","3":"status-publish","4":"format-aside","5":"has-post-thumbnail","7":"category-articles","8":"category-dr-harold-gunatillake","9":"tag-dr-harold-gunatillake","10":"tag-fatty-liver","11":"tag-heart","12":"tag-kidneys","13":"tag-mitochondria","14":"tag-mitochondrial-diseases","15":"post_format-post-format-aside"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.7.1 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mitochondrial diseases - By Harold Gunatillake - eLanka<\/title>\n<meta name=\"description\" content=\"Mitochondrial diseases Mitochondria-an organelle found inlarge numbers in most cells, in whichthe biochemical processes of respirationand\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitochondrial diseases - By Harold Gunatillake\" \/>\n<meta property=\"og:description\" content=\"Mitochondrial diseases Mitochondria-an organelle found inlarge numbers in most cells, in whichthe biochemical processes of respirationand\" \/>\n<meta property=\"og:url\" content=\"https:\/\/websitedesigns.com.au\/elankanew\/mitochondrial-diseases-by-harold-gunatillake\/\" \/>\n<meta property=\"og:site_name\" content=\"eLanka\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/eLanka.com.au\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-17T10:42:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-17T10:44:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/websitedesigns.com.au\/elankanew\/wp-content\/uploads\/2023\/07\/Mitochondrial-diseases-eLanka.png\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"eLanka admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"eLanka admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/websitedesigns.com.au\/elankanew\/mitochondrial-diseases-by-harold-gunatillake\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/websitedesigns.com.au\/elankanew\/mitochondrial-diseases-by-harold-gunatillake\/\"},\"author\":{\"name\":\"eLanka admin\",\"@id\":\"https:\/\/websitedesigns.com.au\/elankanew\/#\/schema\/person\/f6e635b74ab35ef88a68a9973cacc5bd\"},\"headline\":\"Mitochondrial diseases &#8211; 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