{"id":52938,"date":"2020-11-18T12:59:21","date_gmt":"2020-11-18T12:59:21","guid":{"rendered":"https:\/\/websitedesigns.com.au\/elankanew\/?p=52938"},"modified":"2023-06-28T14:53:58","modified_gmt":"2023-06-28T14:53:58","slug":"what-are-angiotensin-inhibitors-and-angiotensin-11-receptor-blockers-by-dr-harold-gunatillake","status":"publish","type":"post","link":"https:\/\/websitedesigns.com.au\/elankanew\/what-are-angiotensin-inhibitors-and-angiotensin-11-receptor-blockers-by-dr-harold-gunatillake\/","title":{"rendered":"What are Angiotensin inhibitors and Angiotensin 11 receptor Blockers?-By Dr Harold Gunatillake"},"content":{"rendered":"<h1 style=\"text-align: center;\"><span style=\"color: #008080;\"> What are Angiotensin inhibitors and Angiotensin 11 receptor Blockers?-By Dr Harold Gunatillake<\/span><\/h1>\n<p><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-77916\" src=\"https:\/\/websitedesigns.com.au\/elankanew\/wp-content\/uploads\/2021\/11\/Harold-Gunethilake.jpg\" alt=\"Harold-Gunethilake\" width=\"160\" height=\"160\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/JeqFXTNMxjw\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Transcript:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">When you are over 60, high blood pressure also called Essential hypertension is most likely to occur in men and women equally. There is no identifiable cause, but is thought to be linked to genetics, poor diet, lack of exercise obesity and stress factors.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It is a silent killer, unless BP is checked regularly and treated with antihypertensive medication if the readings are above the normal range and lifestyle changes.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Other inevitable causes are insulin resistance, high alcohol intake, high salt intake, aging, low potassium, and calcium intake<\/span><!--more--><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Now let us go deeper into the subject of primary medication for high blood pressure and how they work.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It is important to know what medication your doctor has prescribed for any ailment and seek knowledge how those drugs work in your body and their side effects.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Having such prior knowledge seem to help psychologically.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">This talk is about knowing how angiotensin inhibiters and angiotensin receptor blockers, the most common primary anti-hypertensive medication most over 60\u2019s are prescribed.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Your liver creates and releases a protein called <strong><em>angiotensinogen<\/em><\/strong>, repeat angiotensinogen. It means a protein secreted in the liver that tenses the arteries. It is released into your blood stream and is available for action anytime.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It assists in vasoconstriction and an increase in blood pressure. Vasoconstriction means narrowing of the arteries to increase peripheral resistance.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensinogen becomes active at moments you bleed accidently. Prompt narrowing of arteries help to reduce the volume of blood lost, and divert the blood to the brain and heart and other internal organs.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensinogen is broken by an enzyme secreted by the kidneys called renin into angiotensin 1<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Renin also stimulates the release of aldosterone from the adrenal cortex.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Adrenal gland is situated like a cap on the kidneys.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">The main function of aldosterone is to regulate salt and water in the body that influences blood pressure.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">So, repeating-Renin breaks or cleave the angiotensinogen produced by the liver to form angiotensin 1<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensin 1 is physiologically inactive but acts as a precursor for angiotensin 11.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">This process of converting angiotensin 1 into angiotensin11 is catalyzed by an enzyme called <strong><em>angiotensin converting enzyme or ACE.<\/em><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">ACE is found in the inner lining of blood vessels of the lungs and kidneys.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">The drug referred to as ACE inhibitors inhibits the action of angiotensin- converting enzyme, thus decreasing the production of angiotensin 11.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensin 11 increases the blood pressure by constricting the blood vessels. It can also trigger thirst or the desire for salt.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It is a powerful substance. It circulates around the body in the bloodstream and induces several changes on the cardiovascular system.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">These ACE inhibitor enzyme drugs help relax your veins and arteries to lower your blood pressure.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">They are effective in the treatment of other cardiovascular and kidney problems.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">The treatment plan for cardiovascular disease, including high blood pressure is based on an ACE INHIBITOR, A CALCIUM CHANNEL BLOCKER, A BETA BLOCKER, AND A LONG ACTING NITRATE with different combinations on each patient\u2019s requirements.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">ACE inhibitor drugs usually show quick results in hypertensive patients<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Not only for hypertension and congestive heart failure, BUT ACE inhibitors are ALSO given to patients to help prevent a heart attack.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">They are also given to patients after myocardial infarction because ACE inhibitors have proven to hinder inflammation and encourage growth of new blood vessels.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">There are side effects of ACE inhibitors in some patients;<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Nausea<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Drowsiness<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">High levels of blood potassium<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Low blood pressure<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Dizziness<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Headache<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Weakness<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Rash<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Couch<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Altered taste sensations<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensin 11 acts on the adrenal cortex, a gland located on top of each kidney. This gland produces sex hormones, cortisol, and aldosterone<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Aldosterone sends signals to the kidneys resulting in the kidneys absorbing more sodium and water into the blood stream and releasing potassium into the urine.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Aldactone is a drug that acts by working against a hormone called aldosterone. Too much aldosterone causes increased amounts of sodium (a mineral) and water to be retained by the kidneys, while too much potassium is removed from the body. Aldactone works against the effects of aldosterone.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It is a drug of choice given to reduce heart pateints to get rid of excess water and sodium from the body and retain potassium.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Lasix another common drug prescribed for the same situation gets rid of essential potassium also from the body.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">The renin-angiotensin-aldosterone becomes a system and referred to as RAAS is a critical regulator of blood volume , arterial tone blood pressure and fluid balance.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">It does this by increasing sodium and water reabsorption, and vascular tone, meaning increased resistance.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Now let us talk about the Angiotensin 11 blockers used to control high blood pressure and used for heart disease.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Angiotensin 11 receptor blockers block the action of the angiotensin11 at the receptor site to reduce the blood pressure.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">The receptor blocker drugs end as \u2018tans\u2019 to recognize from the inhibitors ending as \u2018prils\u2019<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Common angiotensin 11 receptor blocking drugs are candesartan, Atacand, irbesartan, Avapro, losartan, Micadia Cozaar and vasartan and Diovan.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Side effects:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #000000;\">Unlike the inhibitors these receptor blockers are well tolerated. The incidence of cough is much less with these blockers. Kidney function is not affected by them. Central nervous system side effects such as headaches, dizziness and fatigue can arise as with the ACE inhibitors.<\/span><\/p>\n<p><span style=\"font-size: 20px; color: #333333;\">Website:<a style=\"color: #333333;\" href=\"http:\/\/www.Doctorharold.com\">www.Doctorharold.com<\/a><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #333333;\"><em>Disclaimer:<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 20px; color: #333333;\"><em>The information contained in this article is for general information purposes only, and whilst the author will endeavour to keep the information up to date and correct, eLanka makes no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the eLanka website or the information, products, services, or related graphics contained in this article for any purpose. Any reliance you place on such information is therefore strictly at your own risk. In otherwords, eLanka In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website \/ article. Also please note that through this website \/ web page articles you are able to link to other websites which are not under the control of eLanka and therefore we have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them<\/em><\/span><\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>What are Angiotensin inhibitors and Angiotensin 11 receptor Blockers?-By Dr Harold Gunatillake &nbsp; Transcript: When you are over 60, high blood pressure also called Essential hypertension is most likely to occur in men and women equally. There is no identifiable cause, but is thought to be linked to genetics, poor diet, lack of exercise obesity [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":116942,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"footnotes":""},"categories":[20,1103],"tags":[647,3611],"class_list":{"0":"post-52938","1":"post","2":"type-post","3":"status-publish","4":"format-aside","5":"has-post-thumbnail","7":"category-articles","8":"category-dr-harold-gunatillake","9":"tag-harold-gunatillake","10":"tag-high-blood-pressure","11":"post_format-post-format-aside"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.7.1 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What are Angiotensin inhibitors and Angiotensin 11 receptor Blockers?-By Dr Harold Gunatillake<\/title>\n<meta name=\"description\" content=\"When you are over 60, high blood pressure also called Essential 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