{"id":84911,"date":"2022-01-22T18:15:44","date_gmt":"2022-01-22T18:15:44","guid":{"rendered":"https:\/\/websitedesigns.com.au\/elankanew\/?p=84911"},"modified":"2022-01-22T18:15:44","modified_gmt":"2022-01-22T18:15:44","slug":"omicron-and-immunity-2","status":"publish","type":"post","link":"https:\/\/websitedesigns.com.au\/elankanew\/omicron-and-immunity-2\/","title":{"rendered":"Omicron and Immunity"},"content":{"rendered":"<h1 style=\"text-align: center;\"><span style=\"color: #000000;\">Omicron and Immunity<\/span><\/h1>\n<p style=\"text-align: center;\"><span style=\"font-size: 20px; color: #000000;\">The case for updating covid-19 vaccines for the Omicron variant<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 20px; color: #000000;\">A new study puts the variant in a group apart from its predecessors<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Variants vary, but how much? Since SARS-COV-2 was first sequenced at the beginning of 2020 dozens of versions have been identified. Five have been designated \u201cvariants of concern\u201d by the World Health Organisation (WHO). The latest is Omicron, which was given its name in November last year and looks set to become the dominant form of the virus almost everywhere.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">One question occupying both scientists and politicians is whether covid vaccines would work even better if they were updated to deal with novel variants. Up to and including Delta, first identified in India, and designated a variant of concern in May 2021, the answer has been \u201cno\u201d. But new research, which has mapped differences between all of the important versions of SARS-COV-2, suggests that, although administering existing vaccines is still useful, Omicron is so different from the others that the answer might now be \u201cyes\u201d.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">Researchers in the Netherlands, co-ordinated by Rogier Sanders and Colin Russell of the University of Amsterdam and Dirk Eggink of the Dutch Public Health Institute, acquired blood samples collected from 51 unvaccinated people shortly after they had been infected with various versions of SARS-COV-2. These included the original, ancestral, strain and the Alpha, Beta, Gamma and Delta variants. (Omicron samples were not available.) They then assessed the antibody response (\u201cneutralizing capacity\u201d) of those samples against different antigens\u2014in other words, different versions of the virus, again using the ancestral strain, Alpha, Beta, Gamma and Delta and, this time, Omicron.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">By measuring the neutralizing capacity of the serum of each participant against the various variants and applying what is known as a multidimensional scaling algorithm, Dr Sanders, Dr Russell, Dr Eggink and their colleagues were able to position both the viruses and the serum samples on an \u201cantigenic map\u201d (see chart on page 2). This is used to study how mutations make viruses more or less different from the ancestral strain, in a process called antigenic drift. In such maps, one unit of distance is equivalent to a two-fold change in neutralization titre (a measure of the concentration of antibodies in the blood needed to neutralize a virus). Samples plotted closer together are more similar. Going by a measure conventionally used to group influenza viruses\u2014a distance of three or fewer antigenic units\u2014the researchers found that Omicron would count as the first of a new group of SARS-COV-2. Whereas all widely circulating variants before it, being less than three units apart from each other, cluster as a single group, Omicron is more than five units away from all others.<\/span><\/p>\n<p><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-84912\" src=\"https:\/\/websitedesigns.com.au\/elankanew\/wp-content\/uploads\/2022\/01\/Omicron-and-Immunity.jpg\" alt=\"Omicron and Immunity\" width=\"522\" height=\"613\" \/><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">A paper describing this research was uploaded to <em>medRxiv<\/em>, a research portal, on January 3rd, but has not yet been peer-reviewed. The authors also caution that their methods vary slightly from those conventionally used to map influenza. Nevertheless they conclude that \u201cthe change in neutralization between Omicron and other variants of SARS-COV-2, including the ancestral strain, is striking\u201d. (A separate investigation, published on the same day in <em>Cell<\/em>, reaches a similar conclusion.) Dr Russell cautions that the study\u2019s findings should not be interpreted to mean that existing vaccinations, designed for the ancestral strain, are ineffective. \u201cOmicron\u2019s substantial reduction in cross-reactivity with previous variants doesn\u2019t mean that there is no reactivity. This is probably why boosting with current vaccines provides some protection,\u201d he says.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 16px; color: #000000;\">As more people catch Omicron or are vaccinated, so more of the population will have some protection than in the past. Other studies have also shown that the response of another part of the immune system, its t-cells, seems less affected by Omicron\u2019s mutations. That is probably one reason why Omicron rarely causes severe disease and death in those who have acquired immunity through infection or vaccination. The other is that Omicron itself seems to be inherently less lethal. But, just as twice a year the WHO organizes expert reviews of influenza viruses and issues recommendations on how to tweak vaccine compositions, Dr Russell proposes something similar for covid vaccines. For maximum efficacy, he suggests, vaccines should be updated as soon as possible.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Omicron and Immunity The case for updating covid-19 vaccines for the Omicron variant A new study puts the variant in a group apart from its predecessors Variants vary, but how much? Since SARS-COV-2 was first sequenced at the beginning of 2020 dozens of versions have been identified. Five have been designated \u201cvariants of concern\u201d by [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":84912,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"footnotes":""},"categories":[20],"tags":[41310,41311,41312,35780],"class_list":{"0":"post-84911","1":"post","2":"type-post","3":"status-publish","4":"format-aside","5":"has-post-thumbnail","7":"category-articles","8":"tag-dr-russell","9":"tag-dr-sanders","10":"tag-omicron-and-immunity","11":"tag-world-health-organisation","12":"post_format-post-format-aside"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.7.1 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Omicron and Immunity<\/title>\n<meta name=\"description\" content=\"Variants vary, but how much? 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